over 100x the expression of traditional non-viral DNA
Invisible to immune sensors that detect foreign DNA
Months to years of expression from a single dose; safely re-dosable
Low manufacturing complexity and proven LNP technology
Engage’s Tethosome platform solves the two key hurdles that have held back the field of non-viral DNA: potency and toxicity. Using proven LNP technology, we deliver a therapeutic DNA and an mRNA encoding our proprietary Tethosome protein. This protein localizes DNA to the nucleus, increasing expression by over 100-fold. Critically, our Tethosome platform is invisible to immune sensors which detect foreign DNA and which can cause lethal immune reactions. This allows us to safely deliver potent DNA, re-dose when needed, and titrate expression to optimal levels.
LNP delivers therapeutic DNA and Tethosome mRNA to cells
Tethosome protein is translated and tethers DNA to the nucleus while evading immune sensors
Therapeutic DNA is expressed
We believe that improving the lives of patients is the most valuable goal we can aspire to – and we’re looking for others who share our passion. If your life’s mission is to tackle difficult, but important challenges in human health, please reach out to us.
